Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis.
نویسندگان
چکیده
Hydrazinolysis of unactivated amide bonds is significantly accelerated by the addition of ammonium salts. The reactions proceed at 50-70 °C to give amines with broad substrate scope that outperforms existing amide bond cleavage reactions. Application to peptide and amino sugar derivatives is also demonstrated.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 84 شماره
صفحات -
تاریخ انتشار 2014